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KMID : 0360220200610080861
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Journal of the Korean Ophthalmological Society
2020 Volume.61 No. 8 p.861 ~ p.867
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Cellular Senescence in Pterygium
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Kim Jong-Heon
Lee Soo-Jin
Lee Kyoo-Won
Kim Jae-Chan
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Abstract
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Purpose: To determine cellular senescence in pterygium by studying the expression of senescence-related markers.
Methods: Impression cytology was performed on 28 eyes of 28 patients diagnosed with pterygium or pinguecula from August 2019 to January 2020. From the obtained specimen, the expression of senescence-associated beta galactosidase (SA-β-gal), p16, and interleukin (IL)-1β was examined.
Results: The average percentage of SA-β-gal positive cells was significantly higher for the pterygium group (67.63 ± 16.61%) compared to the control group (32.64 ± 8.98%) (p < 0.01). The fluorescent expression intensity of IL-1β was higher in the pterygium group (22.53 ± 19.21) compared to the control group (11.38 ± 6.30) (p = 0.02), and the p16 fluorescence expression intensity was also higher in the pterygium group, showing 42.79 ± 23.65, compared to the control group values (26.73 ± 18.34) (p = 0.01).
Conclusions: Cellular senescence specific markers, SA-β-gal, IL-1β, and p16, were expressed in pterygium, indicating a new possible framework for the development and progression of pterygium.
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KEYWORD
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Cellular senescence, Interleukin (IL)-1β, p16, Pterygium, Senescence-associated beta galactosidase
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